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INSULIN CONTROLS THE SPATIAL DISTRIBUTION OF GLUT4 ON THE CELL SURFACE THROUGH REGULATION OF ITS POST-FUSION DISPERSAL

While the glucose transporter-4 (GLUT4) is fundamental to insulin-regulated glucose metabolism, its dynamic spatial organization in the plasma membrane (PM) is unclear. Here, using multi-color TIRF microscopy in transfected adipose cells, we demonstrate that insulin regulates not only the exocytosis...

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Detalhes bibliográficos
Main Authors: Stenkula, Karin G., Lizunov, Vladimir A., Cushman, Samuel W., Zimmerberg, Joshua
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427691/
https://ncbi.nlm.nih.gov/pubmed/20816091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.08.005
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