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Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8(+) T Cell Exhaustion versus Memory

Exhausted CD8(+) T cells function poorly and are negatively regulated by inhibitory receptors. Transcriptional profiling has identified gene expression changes associated with exhaustion. However, the transcriptional pathways critical to the differences between exhausted and functional memory CD8(+)...

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Autori principali: Doering, Travis A., Crawford, Alison, Angelosanto, Jill M., Paley, Michael A., Ziegler, Carly G., Wherry, E. John
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749234/
https://ncbi.nlm.nih.gov/pubmed/23159438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.08.021
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