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Structural Phylogenomics Retrodicts the Origin of the Genetic Code and Uncovers the Evolutionary Impact of Protein Flexibility

The genetic code shapes the genetic repository. Its origin has puzzled molecular scientists for over half a century and remains a long-standing mystery. Here we show that the origin of the genetic code is tightly coupled to the history of aminoacyl-tRNA synthetase enzymes and their interactions with...

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Autors principals: Caetano-Anollés, Gustavo, Wang, Minglei, Caetano-Anollés, Derek
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749098/
https://ncbi.nlm.nih.gov/pubmed/23991065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072225
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