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Structural Phylogenomics Retrodicts the Origin of the Genetic Code and Uncovers the Evolutionary Impact of Protein Flexibility

The genetic code shapes the genetic repository. Its origin has puzzled molecular scientists for over half a century and remains a long-standing mystery. Here we show that the origin of the genetic code is tightly coupled to the history of aminoacyl-tRNA synthetase enzymes and their interactions with...

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Detalhes bibliográficos
Main Authors: Caetano-Anollés, Gustavo, Wang, Minglei, Caetano-Anollés, Derek
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749098/
https://ncbi.nlm.nih.gov/pubmed/23991065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072225
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