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The length of the calmodulin linker determines the extent of transient interdomain association and target affinity
Calmodulin (CaM), the prototypical calcium sensing protein in eukaryotes, comprises two domains separated by a short flexible linker, which allows CaM to assume a wide range of extended and compact conformations. Here we use NMR relaxation measurements to explore the role of the linker in CaM functi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3748814/ https://ncbi.nlm.nih.gov/pubmed/23782151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4051422 |
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