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The length of the calmodulin linker determines the extent of transient interdomain association and target affinity

Calmodulin (CaM), the prototypical calcium sensing protein in eukaryotes, comprises two domains separated by a short flexible linker, which allows CaM to assume a wide range of extended and compact conformations. Here we use NMR relaxation measurements to explore the role of the linker in CaM functi...

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Bibliografski detalji
Glavni autori: Anthis, Nicholas J., Clore, G. Marius
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748814/
https://ncbi.nlm.nih.gov/pubmed/23782151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4051422
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