Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing

Human leukocyte antigen B (HLA-B) is a gene that encodes a cell surface protein involved in presenting antigens to the immune system. The variant allele HLA-B*15:02 is associated with an increased risk of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in response to carbamazepin...

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Main Authors: Leckband, S G, Kelsoe, J R, Dunnenberger, H M, George, A L, Tran, E, Berger, R, Müller, D J, Whirl-Carrillo, M, Caudle, K E, Pirmohamed, M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
CPIC Guidelines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748365/
https://ncbi.nlm.nih.gov/pubmed/23695185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.103
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