Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update

The variant allele HLA-B*15:02 is strongly associated with greater risk of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients treated with carbamazepine or oxcarbazepine. The variant allele HLA-A*31:01 is associated with greater risk of maculopapular exanthema, drug reac...

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Publicado no:Clin Pharmacol Ther
Main Authors: Phillips, Elizabeth J., Sukasem, Chonlaphat, Whirl-Carrillo, Michelle, Müller, Daniel J., Dunnenberger, Henry M., Chantratita, Wasun, Goldspiel, Barry, Chen, Yuan-Tsong, Carleton, Bruce C., George, Alfred L., Mushiroda, Taisei, Klein, Teri, Gammal, Roseann S., Pirmohamed, Munir
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847474/
https://ncbi.nlm.nih.gov/pubmed/29392710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1004
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