Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1

Protein arginine methyltransferase 1 (PRMT1), the major arginine asymmetric dimethylation enzyme in mammals, is emerging as a potential drug target for cancer and cardiovascular disease. Understanding the catalytic mechanism of PRMT1 will facilitate inhibitor design. However, detailed mechanisms of...

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Main Authors: Zhang, Ruihan, Li, Xin, Liang, Zhongjie, Zhu, Kongkai, Lu, Junyan, Kong, Xiangqian, Ouyang, Sisheng, Li, Lin, Zheng, Yujun George, Luo, Cheng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748068/
https://ncbi.nlm.nih.gov/pubmed/23977297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072424
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