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Design of Cyclic Peptides That Bind Protein Surfaces with Antibody-Like Affinity
There is a pressing need for new molecular tools to target protein surfaces with high affinity and specificity. Here, we describe cyclic messenger RNA display with a trillion-member covalent peptide macrocycle library. Using this library, we have designed a number of high-affinity, redox-insensitive...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3747972/ https://ncbi.nlm.nih.gov/pubmed/17894440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb7001126 |
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