Cyclic peptide formation catalyzed by an antibody ligase

Cyclic hexapeptides represent a class of compounds with important, diverse biological activities. We report herein that the antibody 16G3 catalyzes the cyclization of d-Trp-Gly-Pal-Pro-Gly-Phe⋅p-nitrophenyl ester (8a) to give c-(d-Trp-Gly-Pal-Pro-Gly-l-Phe) (11a). The antibody does not, however, cat...

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Main Authors: Smithrud, David B., Benkovic, Patricia A., Benkovic, Stephen J., Roberts, Victoria, Liu, Josephine, Neagu, Irina, Iwama, Seiji, Phillips, Barton W., Smith, Amos B., Hirschmann, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15735/
https://ncbi.nlm.nih.gov/pubmed/10688882
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