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Cyclic peptide formation catalyzed by an antibody ligase

Cyclic hexapeptides represent a class of compounds with important, diverse biological activities. We report herein that the antibody 16G3 catalyzes the cyclization of d-Trp-Gly-Pal-Pro-Gly-Phe⋅p-nitrophenyl ester (8a) to give c-(d-Trp-Gly-Pal-Pro-Gly-l-Phe) (11a). The antibody does not, however, cat...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Smithrud, David B., Benkovic, Patricia A., Benkovic, Stephen J., Roberts, Victoria, Liu, Josephine, Neagu, Irina, Iwama, Seiji, Phillips, Barton W., Smith, Amos B., Hirschmann, Ralph
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2000
Onderwerpen:
Physical Sciences
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15735/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688882/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040534397
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