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Engineered Cystine-Knot Peptides That Bind αvβ3 Integrin With Antibody-Like Affinities
The αvβ3 integrin receptor is an important cancer target due to its overexpression on many solid tumors and the tumor neovasculature, and its role in metastasis and angiogenesis. We used a truncated form of the Agouti-related protein (AgRP), a 4 kDa cystine-knot peptide with four disulfide bonds and...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2925133/ https://ncbi.nlm.nih.gov/pubmed/19038268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.11.004 |
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