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Towards Optimization of Arylamides As Novel, Potent, and Brain-Penetrant Antiprion Lead Compounds
[Image: see text] The prion diseases caused by PrP(Sc), an alternatively folded form of the cellular prion protein (PrP(C)), are rapidly progressive, fatal, and untreatable neurodegenerative disorders. We employed HTS ELISA assays to identify compounds that lower the level of PrP(Sc) in prion-infect...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2013
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746989/ https://ncbi.nlm.nih.gov/pubmed/23977416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300454k |
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