PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB

The ubiquitous inducible transcription factor NF-κB plays central roles in immune and inflammatory responses and in tumorigenesis. Complex posttranslational modifications of the p65 subunit (RelA) are a major aspect of the extremely flexible regulation of NF-κB activity. Although phosphorylation, ac...

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Autors principals: Wei, Han, Wang, Benlian, Miyagi, Masaru, She, Yun, Gopalan, Banu, Huang, De-Bin, Ghosh, Gourisankar, Stark, George R., Lu, Tao
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746871/
https://ncbi.nlm.nih.gov/pubmed/23904475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311784110
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