Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms

Macrophages in granulomas are both anti-mycobacterial effector and host cell for Mycobacterium tuberculosis(M.tb), yet basic aspects of macrophage diversity and function within the complex structures of granulomas remain poorly understood. To address this, we examined myeloid cell phenotypes and exp...

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Bibliografiske detaljer
Main Authors: Mattila, Joshua T., Ojo, Olabisi O., Kepka-Lenhart, Diane, Marino, Simeone, Kim, Jin Hee, Eum, Seok Yong, Via, Laura E., Barry, Clifton E., Klein, Edwin, Kirschner, Denise E., Morris, Sidney M., Lin, Philana Ling, Flynn, JoAnne L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746594/
https://ncbi.nlm.nih.gov/pubmed/23749634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300113
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