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Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation

Alternative splicing contributes to cell type-specific transcriptomes. Here, we show that changes in intragenic chromatin marks affect NCAM (neural cell adhesion molecule) exon 18 (E18) alternative splicing during neuronal differentiation. An increase in the repressive marks H3K9me2 and H3K27me3 alo...

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Hlavní autoři: Schor, Ignacio E, Fiszbein, Ana, Petrillo, Ezequiel, Kornblihtt, Alberto R
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746202/
https://ncbi.nlm.nih.gov/pubmed/23892457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.167
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