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Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing

In search for physiological pathways affecting alternative splicing through its kinetic coupling with transcription, we found that membrane depolarization of neuronal cells triggers the skipping of exon 18 from the neural cell adhesion molecule (NCAM) mRNA, independently of the calcium/calmodulin pr...

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Detalhes bibliográficos
Main Authors: Schor, Ignacio E., Rascovan, Nicolás, Pelisch, Federico, Alló, Mariano, Kornblihtt, Alberto R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2657401/
https://ncbi.nlm.nih.gov/pubmed/19251664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810666106
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