Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction A Critical Role of the Angiotensin II/AT1 Receptor Axis

RATIONALE: Diabetic cardiovascular complications are reaching epidemic proportions. Angiotensin-converting enzyme-2 (ACE2) is a negative regulator of the renin-angiotensin system. We hypothesize that loss of ACE2 exacerbates cardiovascular complications induced by diabetes. OBJECTIVE: To define the...

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Hauptverfasser: Patel, Vaibhav B., Bodiga, Sreedhar, Basu, Ratnadeep, Das, Subhash K., Wang, Wang, Wang, Zuocheng, Lo, Jennifer, Grant, Maria B., Zhong, JiuChang, Kassiri, Zamaneh, Oudit, Gavin Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746191/
https://ncbi.nlm.nih.gov/pubmed/22474255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.268029
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