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Loss of TIMP3 selectively exacerbates diabetic nephropathy
Diabetic nephropathy is the most common cause of end-stage renal disease. Polymorphism in the tissue inhibitor of metalloproteinase-3 (TIMP3) gene, and the ECM-bound inhibitor of matrix metalloproteinases (MMPs), has been linked to diabetic nephropathy in humans. To elucidate the mechanism, we gener...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Physiological Society
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518187/ https://ncbi.nlm.nih.gov/pubmed/22896043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00349.2012 |
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