Loss of TIMP3 selectively exacerbates diabetic nephropathy

Diabetic nephropathy is the most common cause of end-stage renal disease. Polymorphism in the tissue inhibitor of metalloproteinase-3 (TIMP3) gene, and the ECM-bound inhibitor of matrix metalloproteinases (MMPs), has been linked to diabetic nephropathy in humans. To elucidate the mechanism, we gener...

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Detalhes bibliográficos
Main Authors: Basu, Ratnadeep, Lee, Jiwon, Wang, Zuocheng, Patel, Vaibhav B., Fan, Dong, Das, Subhash K., Liu, George C., John, Rohan, Scholey, James W., Oudit, Gavin Y., Kassiri, Zamaneh
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518187/
https://ncbi.nlm.nih.gov/pubmed/22896043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00349.2012
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