Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II

Aortic aneurysm is dilation of the aorta primarily due to degradation of the aortic wall extracellular matrix (ECM). Tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), the proteases that degrade the ECM. Timp3 is the only ECM-bound Timp, and its levels are alte...

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Detalhes bibliográficos
Main Authors: Basu, Ratnadeep, Fan, Dong, Kandalam, Vijay, Lee, Jiwon, Das, Subhash K., Wang, Xiuhua, Baldwin, Troy A., Oudit, Gavin Y., Kassiri, Zamaneh
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531724/
https://ncbi.nlm.nih.gov/pubmed/23144462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425652
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