Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II

Aortic aneurysm is dilation of the aorta primarily due to degradation of the aortic wall extracellular matrix (ECM). Tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases (MMPs), the proteases that degrade the ECM. Timp3 is the only ECM-bound Timp, and its levels are alte...

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Bibliographische Detailangaben
Hauptverfasser: Basu, Ratnadeep, Fan, Dong, Kandalam, Vijay, Lee, Jiwon, Das, Subhash K., Wang, Xiuhua, Baldwin, Troy A., Oudit, Gavin Y., Kassiri, Zamaneh
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531724/
https://ncbi.nlm.nih.gov/pubmed/23144462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.425652
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