Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction

Extracellular matrix (ECM) remodeling is a critical aspect of cardiac remodeling following myocardial infarction. Tissue inhibitors of metalloproteinases (TIMPs) are physiological inhibitors of matrix metalloproteinases (MMPs) that degrade the ECM proteins. TIMP3 is highly expressed in the heart, an...

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Bibliografiske detaljer
Main Authors: Kandalam, Vijay, Basu, Ratnadeep, Abraham, Thomas, Wang, Xiuhua, Awad, Ahmed, Wang, Wei, Lopaschuk, Gary D., Maeda, Nobuyo, Oudit, Gavin Y., Kassiri, Zamaneh
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116393/
https://ncbi.nlm.nih.gov/pubmed/20675565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00246.2010
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