Antagonism of angiotensin 1–7 prevents the therapeutic effects of recombinant human ACE2

Activation of the angiotensin 1–7/Mas receptor (MasR) axis counteracts angiotensin II (Ang II)-mediated cardiovascular disease. Recombinant human angiotensin-converting enzyme 2 (rhACE2) generates Ang 1–7 from Ang II. We hypothesized that the therapeutic effects of rhACE2 are dependent on Ang 1–7 ac...

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Bibliografski detalji
Izdano u:J Mol Med (Berl)
Glavni autori: Patel, Vaibhav B., Takawale, Abhijit, Ramprasath, Tharmarajan, Das, Subhash K., Basu, Ratnadeep, Grant, Maria B., Hall, David A., Kassiri, Zamaneh, Oudit, Gavin Y
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580513/
https://ncbi.nlm.nih.gov/pubmed/25874965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-015-1285-z
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