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The Organic Cation Transporter, OCTN1, Expressed in the Human Heart, Potentiates Antagonism of the HERG Potassium Channel
BACKGROUND: Variable function and expression of drug transporters have been proposed as mechanisms contributing to variable response to drug therapy. Block of the HERG channel, encoding I(Kr), can lead to serious arrhythmias, and a key drug-blocking site in HERG has been identified on the intracellu...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3745652/ https://ncbi.nlm.nih.gov/pubmed/19528813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3181abc288 |
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