Selective Regulation of Cardiac Organic Cation Transporter Novel Type 2 (OCTN2) in Dilated Cardiomyopathy

Organic cation transporters (OCT1-3 and OCTN1/2) facilitate cardiac uptake of endogenous compounds and numerous drugs. Genetic variants of OCTN2, for example, reduce uptake of carnitine, leading to heart failure. Whether expression and function of OCTs and OCTNs are altered by disease has not been e...

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Main Authors: Grube, Markus, Ameling, Sabine, Noutsias, Michel, Köck, Kathleen, Triebel, Ivonne, Bonitz, Karina, Meissner, Konrad, Jedlitschky, Gabriele, Herda, Lars R., Reinthaler, Markus, Rohde, Maria, Hoffmann, Wolfgang, Kühl, Uwe, Schultheiss, Heinz-Peter, Völker, Uwe, Felix, Stephan B., Klingel, Karin, Kandolf, Reinhard, Kroemer, Heyo K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124333/
https://ncbi.nlm.nih.gov/pubmed/21641380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.02.020
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