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Evaluation of warfarin resistance using TALENs-mediated vitamin K epoxide reductase knockout HEK293 cells

BACKGROUND: Single nucleotide polymorphisms in the vitamin K epoxide reductase (VKOR) gene have been successfully used for warfarin dosage prediction. However, warfarin resistance studies of naturally occurring VKOR mutants do not correlate with their clinical phenotype. This discrepancy presumably...

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Detalhes bibliográficos
Main Authors: Tie, Jian-Ke, Jin, Da-Yun, Tie, Kevin, Stafford, Darrel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745541/
https://ncbi.nlm.nih.gov/pubmed/23710884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12306
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