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Evaluation of warfarin resistance using TALENs-mediated vitamin K epoxide reductase knockout HEK293 cells

BACKGROUND: Single nucleotide polymorphisms in the vitamin K epoxide reductase (VKOR) gene have been successfully used for warfarin dosage prediction. However, warfarin resistance studies of naturally occurring VKOR mutants do not correlate with their clinical phenotype. This discrepancy presumably...

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Bibliographic Details
Main Authors: Tie, Jian-Ke, Jin, Da-Yun, Tie, Kevin, Stafford, Darrel W.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745541/
https://ncbi.nlm.nih.gov/pubmed/23710884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12306
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