Autoactivation of Mouse Trypsinogens Is Regulated by Chymotrypsin C via Cleavage of the Autolysis Loop

Chymotrypsin C (CTRC) is a proteolytic regulator of trypsinogen autoactivation in humans. CTRC cleavage of the trypsinogen activation peptide stimulates autoactivation, whereas cleavage of the calcium binding loop promotes trypsinogen degradation. Trypsinogen mutations that alter these regulatory cl...

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Autori principali: Németh, Balázs Csaba, Wartmann, Thomas, Halangk, Walter, Sahin-Tóth, Miklós
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745349/
https://ncbi.nlm.nih.gov/pubmed/23814066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478800
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