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A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

Inflammatory diseases of the pancreas have no specific therapy. Discovery of the genetic basis of chronic pancreatitis identified the digestive enzyme trypsin as a therapeutic target. Preclinical testing of trypsin inhibition has been hampered by the lack of animal models. Here we report the T7D23A...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Geisz, Andrea, Sahin-Tóth, Miklós
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261995/
https://ncbi.nlm.nih.gov/pubmed/30487519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07347-y
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