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A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation

Inflammatory diseases of the pancreas have no specific therapy. Discovery of the genetic basis of chronic pancreatitis identified the digestive enzyme trypsin as a therapeutic target. Preclinical testing of trypsin inhibition has been hampered by the lack of animal models. Here we report the T7D23A...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Geisz, Andrea, Sahin-Tóth, Miklós
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261995/
https://ncbi.nlm.nih.gov/pubmed/30487519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07347-y
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