Mitochondrial SIRT4-type proteins in C. elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases

The biological and enzymatic function of SIRT4 is largely uncharacterized. We show that the C. elegans SIR-2.2 and SIR-2.3 orthologs of SIRT4 are ubiquitously expressed, also localize to mitochondria and function during oxidative stress. Further, we identified conserved interaction with mitochondria...

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Bibliografische gegevens
Hoofdauteurs: Wirth, Martina, Karaca, Samir, Wenzel, Dirk, Ho, Linh, Tishkoff, Daniel, Lombard, David B., Verdin, Eric, Urlaub, Henning, Jedrusik-Bode, Monika, Fischle, Wolfgang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744624/
https://ncbi.nlm.nih.gov/pubmed/23438705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2013.02.002
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