Interaction Between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etli()

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to active sites in both the biotin carboxylase domain and the carboxyl transferase...

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Autori principali: Lietzan, Adam D., Menefee, Ann L., Zeczycki, Tonya N., Kumar, Sudhanshu, Attwood, Paul V., Wallace, John C., Cleland, W. Wallace, Maurice, Martin St.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214759/
https://ncbi.nlm.nih.gov/pubmed/21958016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201277j
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