Interaction Between the Biotin Carboxyl Carrier Domain and the Biotin Carboxylase Domain in Pyruvate Carboxylase from Rhizobium etli()

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis, the tethered biotin of PC must gain access to active sites in both the biotin carboxylase domain and the carboxyl transferase...

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Auteurs principaux: Lietzan, Adam D., Menefee, Ann L., Zeczycki, Tonya N., Kumar, Sudhanshu, Attwood, Paul V., Wallace, John C., Cleland, W. Wallace, Maurice, Martin St.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214759/
https://ncbi.nlm.nih.gov/pubmed/21958016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201277j
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