Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS. To characterize MYD88 in MDS, we sequenced the coding region of the MYD88 gene in 40 MDS patients. No...

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Bibliografski detalji
Glavni autori: Dimicoli, Sophie, Wei, Yue, Bueso-Ramos, Carlos, Yang, Hui, DiNardo, Courtney, Jia, Yu, Zheng, Hong, Fang, Zhihong, Nguyen, Martin, Pierce, Sherry, Chen, Rui, Wang, Hui, Wu, Chenghua, Garcia-Manero, Guillermo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744562/
https://ncbi.nlm.nih.gov/pubmed/23976989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071120
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