Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS. To characterize MYD88 in MDS, we sequenced the coding region of the MYD88 gene in 40 MDS patients. No...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Dimicoli, Sophie, Wei, Yue, Bueso-Ramos, Carlos, Yang, Hui, DiNardo, Courtney, Jia, Yu, Zheng, Hong, Fang, Zhihong, Nguyen, Martin, Pierce, Sherry, Chen, Rui, Wang, Hui, Wu, Chenghua, Garcia-Manero, Guillermo
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744562/
https://ncbi.nlm.nih.gov/pubmed/23976989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071120
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