Overexpression of the Toll-Like Receptor (TLR) Signaling Adaptor MYD88, but Lack of Genetic Mutation, in Myelodysplastic Syndromes

MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS. To characterize MYD88 in MDS, we sequenced the coding region of the MYD88 gene in 40 MDS patients. No...

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Detalhes bibliográficos
Main Authors: Dimicoli, Sophie, Wei, Yue, Bueso-Ramos, Carlos, Yang, Hui, DiNardo, Courtney, Jia, Yu, Zheng, Hong, Fang, Zhihong, Nguyen, Martin, Pierce, Sherry, Chen, Rui, Wang, Hui, Wu, Chenghua, Garcia-Manero, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744562/
https://ncbi.nlm.nih.gov/pubmed/23976989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071120
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