Genomic Deregulation of the E2F/Rb Pathway Leads to Activation of the Oncogene EZH2 in Small Cell Lung Cancer

Small cell lung cancer (SCLC) is a highly aggressive lung neoplasm with extremely poor clinical outcomes and no approved targeted treatments. To elucidate the mechanisms responsible for driving the SCLC phenotype in hopes of revealing novel therapeutic targets, we studied copy number and methylation...

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Detaylı Bibliyografya
Asıl Yazarlar: Coe, Bradley P., Thu, Kelsie L., Aviel-Ronen, Sarit, Vucic, Emily A., Gazdar, Adi F., Lam, Stephen, Tsao, Ming-Sound, Lam, Wan L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744458/
https://ncbi.nlm.nih.gov/pubmed/23967231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071670
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