The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain

Apolipoprotein E (APOE) is the major risk factor for sporadic Alzheimer's disease. Among other functions, APOE is proposed to sequester neurotoxic amyloid-β (Aβ) peptides in the brain, delivering them to cellular catabolism via neuronal APOE receptors. Still, the receptors involved in this proc...

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Main Authors: Carlo, Anne-Sophie, Gustafsen, Camilla, Mastrobuoni, Guido, Nielsen, Morten S., Burgert, Tilman, Hartl, Daniela, Rohe, Michael, Nykjaer, Anders, Herz, Joachim, Heeren, Joerg, Kempa, Stefan, Petersen, Claus Munck, Willnow, Thomas E.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744345/
https://ncbi.nlm.nih.gov/pubmed/23283348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2425-12.2013
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