DNA Ligase IV and Artemis Act Cooperatively to Suppress Homologous Recombination in Human Cells: Implications for DNA Double-Strand Break Repair

Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are two major pathways for repairing DNA double-strand breaks (DSBs); however, their respective roles in human somatic cells remain to be elucidated. Here we show using a series of human gene-knockout cell lines that NHEJ repairs nea...

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Detalhes bibliográficos
Main Authors: Kurosawa, Aya, Saito, Shinta, So, Sairei, Hashimoto, Mitsumasa, Iwabuchi, Kuniyoshi, Watabe, Haruka, Adachi, Noritaka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743779/
https://ncbi.nlm.nih.gov/pubmed/23967291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072253
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