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Conformational Changes in the Lower Palm Domain of ASIC1a Contribute to Desensitization and RFamide Modulation
Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel that contributes to fear and pain as well as neuronal damage following persistent cerebral acidosis. Neuropeptides can affect acid-induced neuronal injury by altering ASIC1a inactivation and/or steady-state desensitization. Yet, e...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743763/ https://ncbi.nlm.nih.gov/pubmed/23977127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071733 |
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