Rapid in vivo assessment of drug efficacy against Mycobacterium tuberculosis using an improved firefly luciferase

OBJECTIVES: In vivo experimentation is costly and time-consuming, and presents a major bottleneck in anti-tuberculosis drug development. Conventional methods rely on the enumeration of bacterial colonies, and it can take up to 4 weeks for Mycobacterium tuberculosis to grow on agar plates. Light prod...

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Detalhes bibliográficos
Main Authors: Andreu, Nuria, Zelmer, Andrea, Sampson, Samantha L., Ikeh, Melanie, Bancroft, Gregory J., Schaible, Ulrich E., Wiles, Siouxsie, Robertson, Brian D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743513/
https://ncbi.nlm.nih.gov/pubmed/23633686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkt155
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