Sea Anemone Peptide with Uncommon β-Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic Activity

Three novel peptides were isolated from the venom of the sea anemone Urticina grebelnyi. All of them are 29 amino acid peptides cross-linked by two disulfide bridges, with a primary structure similar to other sea anemone peptides belonging to structural group 9a. The structure of the gene encoding t...

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Autores principales: Osmakov, Dmitry I., Kozlov, Sergey A., Andreev, Yaroslav A., Koshelev, Sergey G., Sanamyan, Nadezhda P., Sanamyan, Karen E., Dyachenko, Igor A., Bondarenko, Dmitry A., Murashev, Arkadii N., Mineev, Konstantin S., Arseniev, Alexander S., Grishin, Eugene V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743484/
https://ncbi.nlm.nih.gov/pubmed/23801332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.485516
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