Sea Anemone Peptide with Uncommon β-Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic Activity

Three novel peptides were isolated from the venom of the sea anemone Urticina grebelnyi. All of them are 29 amino acid peptides cross-linked by two disulfide bridges, with a primary structure similar to other sea anemone peptides belonging to structural group 9a. The structure of the gene encoding t...

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Autori principali: Osmakov, Dmitry I., Kozlov, Sergey A., Andreev, Yaroslav A., Koshelev, Sergey G., Sanamyan, Nadezhda P., Sanamyan, Karen E., Dyachenko, Igor A., Bondarenko, Dmitry A., Murashev, Arkadii N., Mineev, Konstantin S., Arseniev, Alexander S., Grishin, Eugene V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743484/
https://ncbi.nlm.nih.gov/pubmed/23801332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.485516
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