CXCR4 Chemokine Receptor Signaling Induces Apoptosis in Acute Myeloid Leukemia Cells via Regulation of the Bcl-2 Family Members Bcl-X(L), Noxa, and Bak

The CXCR4 chemokine receptor promotes survival of many different cell types. Here, we describe a previously unsuspected role for CXCR4 as a potent inducer of apoptosis in acute myeloid leukemia (AML) cell lines and a subset of clinical AML samples. We show that SDF-1, the sole ligand for CXCR4, indu...

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Détails bibliographiques
Auteurs principaux: Kremer, Kimberly N., Peterson, Kevin L., Schneider, Paula A., Meng, X. Wei, Dai, Haiming, Hess, Allan D., Smith, B. Douglas, Rodriguez-Ramirez, Christie, Karp, Judith E., Kaufmann, Scott H., Hedin, Karen E.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743469/
https://ncbi.nlm.nih.gov/pubmed/23798675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.449926
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