Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

Acute graft-versus-host disease (GVHD) and leukemic relapse are the two major obstacles to successful outcomes after allogeneic bone marrow transplantation (BMT), an effective therapy for hematological malignancies. Several studies have demonstrated that the dysregulation of proinflammatory cytokine...

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Autors principals: Reddy, Pavan, Maeda, Yoshinobu, Hotary, Kevin, Liu, Chen, Reznikov, Leonid L., Dinarello, Charles A., Ferrara, James L. M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC374345/
https://ncbi.nlm.nih.gov/pubmed/15001702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400380101
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