Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

Acute graft-versus-host disease (GVHD) and leukemic relapse are the two major obstacles to successful outcomes after allogeneic bone marrow transplantation (BMT), an effective therapy for hematological malignancies. Several studies have demonstrated that the dysregulation of proinflammatory cytokine...

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Bibliografiske detaljer
Main Authors: Reddy, Pavan, Maeda, Yoshinobu, Hotary, Kevin, Liu, Chen, Reznikov, Leonid L., Dinarello, Charles A., Ferrara, James L. M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC374345/
https://ncbi.nlm.nih.gov/pubmed/15001702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400380101
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