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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Flux through metabolic pathways is inherently sensitive to the levels of specific substrates and products, but cellular metabolismis also managed by integrated control mechanisms that sense the nutrient and energy status of a cell or organism. The mechanistic target of rapamycin (mTOR) complex 1 (mT...

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Bibliographic Details
Main Authors: Dibble, Christian C., Manning, Brendan D.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743096/
https://ncbi.nlm.nih.gov/pubmed/23728461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2763
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