A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high levels in lymphoid malignancies. In a model for p185(BCR-ABL+) B-acute lymphoid leukemia, we show that CDK6 is part of a transcription complex that induces the expression of the tumor suppressor p16(INK4a) and the...

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Main Authors: Kollmann, Karoline, Heller, Gerwin, Schneckenleithner, Christine, Warsch, Wolfgang, Scheicher, Ruth, Ott, Rene G., Schäfer, Markus, Fajmann, Sabine, Schlederer, Michaela, Schiefer, Ana-Iris, Reichart, Ursula, Mayerhofer, Matthias, Hoeller, Christoph, Zöchbauer-Müller, Sabine, Kerjaschki, Dontscho, Bock, Christoph, Kenner, Lukas, Hoefler, Gerald, Freissmuth, Michael, Green, Anthony R., Moriggl, Richard, Busslinger, Meinrad, Malumbres, Marcos, Sexl, Veronika
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743049/
https://ncbi.nlm.nih.gov/pubmed/23948297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.07.012
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