Protein Kinase Cϵ Is Required for Spinal Analgesic Synergy between Delta Opioid and Alpha-2A Adrenergic Receptor Agonist Pairs

We recently showed that spinal synergistic interactions between δ opioid receptors (δORs) and α(2A) adrenergic receptors (α(2A)ARs) require protein kinase C (PKC). To identify which PKC isoforms contribute to analgesic synergy, we evaluated the effects of various PKC-isoform-specific peptide inhibit...

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Autores principales: Schuster, Daniel J., Kitto, Kelley F., Overland, Aaron C., Messing, Robert O., Stone, Laura S., Fairbanks, Carolyn A., Wilcox, George L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2013
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742937/
https://ncbi.nlm.nih.gov/pubmed/23946412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4013-12.2013
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