Targeted Correction of Single-Base-Pair Mutations with Adeno-Associated Virus Vectors under Nonselective Conditions

Recombinant adeno-associated virus (rAAV) vectors possess the unique ability to introduce genetic alterations at sites of homology in genomic DNA through a mechanism thought to predominantly involve homologous recombination. We have investigated the efficiency of this approach using a mutant enhance...

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Main Authors: Liu, Xiaoming, Yan, Ziying, Luo, Meihui, Zak, Roman, Li, Ziyi, Driskell, Ryan R., Huang, Yumao, Tran, Nam, Engelhardt, John F.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2004
主題:
Gene Therapy
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC374254/
https://ncbi.nlm.nih.gov/pubmed/15047832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4165-4175.2004
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