Ubiquitination of both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant Vectors

In the presence of complementing adeno-associated virus type 2 (AAV-2) Rep proteins, AAV-2 genomes can be pseudotyped with the AAV-5 capsid to assemble infectious virions. Using this pseudotyping strategy, the involvement of the ubiquitin-proteasome system in AAV-5 and AAV-2 capsid-mediated infectio...

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Bibliographische Detailangaben
Hauptverfasser: Yan, Ziying, Zak, Roman, Gant Luxton, G. W., Ritchie, Teresa C., Bantel-Schaal, Ursula, Engelhardt, John F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Gene Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC135943/
https://ncbi.nlm.nih.gov/pubmed/11836382
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